A new phenoxazine derivative isolated from marine sediment actinomycetes, Nocardiopsis sp. 236.

نویسندگان

  • C H Lu
  • Y Y Li
  • H X Wang
  • B M Wang
  • Y M Shen
چکیده

During screening of marine actinomycetes for anti-mycobacterial activity, a new phenoxazine derivative (1) was isolated, along with 6-phenazinediol (2), 6-methoxy-1-phenazinol (3), nocardamin (4), and 3-pyridinecarboxylic acid (5), from a culture of Nocardiopsis sp. 236 collected from the west Pacific. The chemical structure of 1 was established on the basis of 1D-, 2D-NMR, and HRQ-TOF MS data. All compounds were evaluated for their anti-mycobacterial activity in vitro, and only compounds 2 and 3 exhibited weak activity.

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عنوان ژورنال:
  • Drug discoveries & therapeutics

دوره 7 3  شماره 

صفحات  -

تاریخ انتشار 2013